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![]() Also, the engineered Kunitz-type inhibitor DX-1000 is being developed as a PEG conjugate 53. Here we review the current state and clinical validation of these next-generation therapeutics.Īdnectin Affibody Anticalin DARPin antibody immunoglobulin. Nevertheless, PEGylation of the Adnectin CT-322 was successfully employed to improve the pharmacokinetics of this small protein scaffold to meet clinical needs 84. This includes the abovementioned pioneering examples as well as designed ankyrin repeat proteins (DARPins). However, despite strong interest from basic science, only a handful of those protein scaffolds have undergone biopharmaceutical development up to the clinical stage. Possibilities of engineered protein scaffolds have been explored in research, diagnostics and therapy in the last few years. These translational developments will be reviewed here. These scaffolds have demonstrated efficacy in preclinical animal models and, in some cases, clinical trials in therapy or imaging. In fact, engineered protein scaffolds with useful binding specificities, mostly directed against targets of biomedical relevance, constitute an area of active research today, which has yielded versatile reagents as laboratory tools. Validated scaffolds include the fibronectin domain, knottin, designed ankyrin repeat protein, anticalin, and affibody among others. Since then, this concept has expanded considerably, including many other protein templates. Early examples were the Affibody, Monobody (Adnectin), and Anticalin proteins, which were derived from fragments of streptococcal protein A, from the tenth type III domain of human fibronectin, and from natural lipocalin proteins, respectively. The concept of engineering robust protein scaffolds for novel binding functions emerged 20 years ago, one decade after the advent of recombinant antibody technology. While it’s not a sporty machine, it will take a corner or two. There is a decent amount of power, and this new Volt has no problem keeping up with the traffic. General Motors listened to past owners and tried to fix those problems. You can cruise around with one window down without that buffeting wind noise that you’d get in the first Volt. There is still some noise, but much less than before. One thing you notice on the road: It’s more hushed on the highway. This engine is a bit smoother and much quieter than before. The new engine is a 1.5L four-cylinder that acts as a generator for the electric motor. You get a little extra range through the Regen on Demand, a paddle on the back of the steering wheel that helps slow and recharge the battery at the same time. The computer said I had a 410-mile range with a fully charged battery and full tank of gas. The EV-only range now jumps to 53 miles, and I saw 57 miles on one charge thanks to some stop-and-go traffic. The new Volt is a step up from the first generation, with a better range in electric mode and overall - and when you need to use gas, it’s regular gas, not the premium grade used by the last Volt. WASHINGTON - The Chevrolet Volt is redesigned with better electric vehicle range to keep you away from the pump longer. It’s an interesting car with an electric motor and small engine that acts as a range extender when you use up all the juice in the batteries.įor 2017, the second year on this new redesign, the Volt sees some options to help improve the driving experience and added safety features. Business & Finance Click to expand menu.Now, less expensive than some competing gasoline cars, it's more compelling than ever. ![]() The Bolt was already, in many ways, the just-right everyday EV. As tested, this 2LT spec with premium audio ($595) and the adaptive cruise control upgrade ($375) has a pre-incentive sticker price of $36,165 - nearly $10K less than any other current member of the 250-mile electric compact club. Only the 40-kWh Nissan Leaf and the Mini Cooper SE are cheaper - and you'll get at least 100 fewer miles with both. Starting at $31,995 (including a $995 destination charge and before any EV tax incentives), the Bolt is $5,500 cheaper than last year and is now the most affordable long-range electric car in its class. However, the best new feature on the 2022 Chevrolet Bolt EV is the lower price. And while I'd like faster DC charging, the slight speed improvements to home charging - where you should get most of your juice anyway - shouldn't be overlooked. New infotainment and the option for adaptive cruise fill gaps in the cabin and safety tech that help to keep this EV competitive. The 2022 Chevy Bolt EV builds atop an already solid affordable EV formula with improved aesthetics and a more upmarket interior. Antuan Goodwin/Roadshow The price is right Many small changes add up to a big difference in the 2022 Bolt, made only more compelling by its new price. The system operates smoothly in stop-and-go traffic and compliments the standard lane-keeping steering assist on the highway. The 2022 model year update sees the addition of adaptive cruise control to the Bolt's bag of optional tricks - a sore omission in previous model years that's now a $375 upgrade for the highest 2LT trim level and the most compelling reason to upgrade from the 1LT base model. Fortunately, the low center of mass, light steering and responsive right pedal keep the Bolt feeling lively on the freeways and urban environments where it'll spend the majority of its time. The Bolt corners well enough, but its hefty weight and low-rolling-resistance tires can be a handful when driving quickly on a twisty mountain pass. ![]() It's a good thing the Bolt is so torquey because the handling is still pretty underwhelming. That's not a dealbreaker - especially considering the Bolt's price and its range between those charges - and at the very least, DC fast charging is now a standard feature, so at least you're not paying more to get it.ĭrivers can now set one-pedal driving as the default mode for better control over regenerative braking. That means getting a boost to 80% capacity at a rapid charge station takes about an hour. Having been spoiled by newer, more upmarket EVs, I was a touch disappointed to learn that the Bolt can still only DC fast charge at around 55 kW max. Of course, you can also trickle charge at almost any standard 110-volt wall outlet, but that only adds around 4 miles of range per hour. This reduces the charge time to around 7 hours versus the 10-hour estimate if you plug the dual-level charging cord straight into a NEMA 14-50 outlet. ![]() Home charging is potentially faster with this year's upgrade to up to 11.5-kW Level 2 charging - though you'll need to make sure that your home can support the extra current and install a 48-amp wall charging unit to take full advantage. Using the Script View, included in the upcoming release, users can generate domain specific visualizations and extend the Sterling interface with user-defined scripts. The liquidus solidus curves are plotted using the regular solution model (eq 1). Experimental points are taken from ref 63. The Table View provides sorting and filtering options, and skolemized variables can be displayed as highlighted rows. Bulk phase diagram of the gold silver alloy. ![]() The Graph View provides multiple layout options, does not restrict the movement of atoms to rows, and maintains the position of common elements when stepping through traces. It also includes enhanced views that make complex state easier to understand. Synopsis: Sterling is a web-based visualizer for Alloy that can be customized and extended using JavaScript.Verification relies on bounded and unbounded model-checking and the Visualizer is extended to allow interactive exploration of traces. Synopsis: Electrum extends Alloy with mutable signatures and fields as well as connectives from Linear Temporal Logic (with Past), it is well suited to model systems featuring both structural and behavioral aspects.This piece is most likely 'electrum,' which is a natural alloy of gold and silver, where the silver makes up over 20 of the alloy. Very Rare This is a beautiful piece of raw gold found in Northern Nevada. Authors: Nuno Macedo, Julien Brunel, David Chemouil, Alcino Cunha Nevada Electrum Natural Gold Nugget 151.38 Grams - 4.86 Troy Ounces.A good example is electrum, a naturally occurring alloy of silver and gold. Alloys made using precious metals are themselves precious. Some sources consider indium to be a precious metal. Rhenium is commonly included on the list. Requires Java 6.Īlloy 4.1 (platform independent). Other elements are sometimes considered to be precious metals. alloy4.2.jarĪlloy 4.2 (platform independent). ![]() Many of these releases no longer work on MacOS out of the box. released versions Latest buildĪlloy 6 (includes the version for macOS High Sierra)Īlloy 5.1.0 (includes the version for macOS High Sierra) To execute, simply double-click on the jar file, or type See the release notes for details of newįeatures. The same jar fileĬan be incorporated into other applications to use Alloy as an API,Īnd includes the source code. Model finder and a variety of SAT solvers, as well as the standardĪlloy library and a collection of tutorial examples. Alloy is a self-contained executable, which includes the Kodkod Think of it as a work management tool - like Asana or Wrike - with extra features to replace other tools in your stack. ClickUpĬlickUp’s the one app to rule them all, a work tool that combines tasks, chat, documents, and more all in one place. But if you do, you can buy 100GB of Google Drive storage for just $1.99/month. Since it’s intended for simple, on-the-go note-taking, you might not find that you need to upgrade your storage. Google Keep is free to use - the only thing you might need to pay for is Google Drive storage. Google Keep can’t handle the kind of in-depth, super-organized notes that Evernote can - but that’s not what it was designed to do, either. Biggest DrawbacksĪs we mentioned, comparing Evernote and Google Keep is a bit like comparing apples and oranges. If you enter a date into your notes, it will pop up on your Google calendar, and you can set location-based reminders, too. However, even if you aren’t diligent about organizing your notes, you can easily search through them to find what you need.īecause it integrates with the rest of Google’s apps, Google Keep is especially great for reminders. You can color-code or label Google Keep’s notes by topic, and they’re also sharable in case you want to collaborate on a note (for example, you could have different family members add to a shopping list). You wouldn’t use Google Keep that way - instead, you’d jot down small bits of information that you want to be easily accessible, like to-do lists or your child’s soccer schedule. As an Evernote alternative, Google Keep is a virtual surface you can cover in short, timely, and actionable digital sticky notes.įor example, you might use Evernote for taking notes during your undergrad psychology lecture or executive leadership retreat. FeaturesĮvernote is kind of like a virtual binder or journal, designed for longer, in-depth notes. These two systems can both help you work better, but they’re designed for very different needs. Google Keep and Evernote are both note-taking apps, but that’s where their similarities end. Need to integrate Notion with other work tools? Here’s how Unito can do it for you. Well worth it if you need its project management capabilities, but maybe not a justifiable expense if you just need a collaborative note-taking app. ![]() Notion’s Team plan costs $8 per user, per month. While Notion does offer a free Personal plan, most people will be using it for team collaboration - and that doesn’t exactly come cheap. If all you want to do is take notes, choosing one of Notion’s templates before you even get started can feel like wasted time - especially if you won’t be making full use of the robust suite of other features it offers. However, that also means that if it’s strictly note-taking you’re looking for, you might prefer Evernote. Thanks to its blank-canvas design and powerful, flexible nature, you can make Notion into whatever you need it to be. Notion really stands out for its customizability. Notion organizes its content into “blocks.” You can organize those blocks however works best for your team, or use one of Notion’s thousands of available templates - including many designed specifically for notes. You can also create a wiki for your team that stores all information relevant to your project in one place. You’ll be able to assign tasks to different team members, and store all different types of content related to your projects, from images to bits of code. But it can help you keep the rest of your work organized, too. FeaturesĪs a tool for taking and sharing notes, Notion is a great alternative to Evernote. Notion keeps everyone informed, in touch, and working collaboratively. While it’s great for note-taking, it’s also a project management tool and digital workspace. Notion is a flexible work platform designed for teams. Here are six Evernote alternatives to consider, if you’re looking to switch to a new note-taking app. Whether you’re looking for a note-taking experience that’s more beautiful, more intuitive, or easier to share, there’s a perfect Evernote alternative out there for you. But no one app can be everything to everybody, and today, there’s a slew of other note-taking apps giving Evernote a run for its money. ![]() Users love its ability to sync notes across devices, handle a wide variety of use cases, and support content like images, audio, and scanned documents. It’s been around for over a decade, and if your work involves any kind of note-taking, you’ve likely heard of it. Evernote is one of the most popular note-taking apps of all time. ![]() ![]() Please note that it is not possible to convert from Pencil+ 3 to Pencil+ 4 with 3ds Max 2014 and older versions as well as with 3ds Max 2018 and newer versions. Standalone version for your own operating system Different builds of Pencils are made for popular operating systems. It has templates for handwritten input as. ![]() We are trying our best to make Pencil available to as many platforms as possible. Pencil Planner & Calendar Pro is an iPad and iPhone daily planner and agenda app for use with the Apple Pencil. To convert data from Pencil+ 3 to Pencil+ 4, you need an environment where both the Pencil+ 3 and Pencil+ 4 plugins are installed and can be used at the same time. Downloads - Pencil Project Get Pencil Pencil is available in many different types of packaging for available desktop operating systems.Please understand that we do not provide any support for this plugin. Download Notes+ for Apple Pencil and enjoy it on your iPhone, iPad and iPod touch. ![]() Develop, manage, and administer databases access, manage, and visually. It enables database developers, database administrators, and data and business analysts to handle their multi-platform databases and the data contained within them. Cree otro activity donde se van a ingresar los datos de usuario y contraeña, y a partir de este quiero que los envíe a la Base de datos. Aqua Data Studio is a universal integrated development environment (IDE) for databases and visual analytics. Create visualizations and dashboards to analyze data with drag-and-drop. View, filter, and edit query results in Excel-like grid with copy-and-paste. AquaFold ofrece un periodo de evaluación plenamente operativo de 14 días. ![]() Easily develop, execute, and share SQL statements. Aqua Data Studio está registrado con una licencia privada comercial. Use a single database tool to manage many tasks for numerous data sources. La aplicación está escrita en el Java, lo que permite su ejecución en Windows, Linux y OSX. ![]() Lo que quiero es hacer que del registro de un usuario que reciba solamente nombre y contraseña logren guardarse los datos en la base de datos y pueda iniciar sesión. Benefits of Aqua Data Studio Database IDE. Aqua Data Studio se conecta con las principales bases de datos relacionales, lo que facilita la realización de consultas SQL, el diseño de la estructura de las bases de datos, la administración de servidor y la comparación y conversión de bases de datos. ![]() For now (and in general) one only needs to focus on the main notation.ġ2 intervals: Listening to the ogg version is less likely to require a file download But these are easy to do once the rules become apparent. For example, a minor sixth is also an augmented fifth and so forth. The difficulty lies in that they each have several ways of being written, which seemingly creates many more. There are 12 unique pitches in Western music (not counting the octave), and therefore only 12 intervals (not counting invervals greater than an octave). Not just recognizing specific intervals but feeling where the melody goes next is crucial for dictation, triad and chord constuction, sight singing, and all that jazz.Īn interval is simply the distance between two pitches. ![]() Learning intervals is arguably the most fundamental and important part of ear training. Toolsĭisplay the chord for a specified starting note, chord type, and key.Ĭreate your own custom tailored staff paper to print out.ĭisplay the twelve-tone matrix for a specified tone row.Ear Training: Intervals Introduction Listen to the played chord and identify its type. Listen to the played scale and identify its type. Listen to the played interval and identify its type. Identify the note name of the highlighted piano key. ![]() Identify the type of the displayed chord. Identify the quality and type of the displayed interval. Watch an analysis Beethoven’s Moonlight Sonata (measures 48-50). Learn how a Neapolitan chord in first inversion is commonly used. Learn how second inversion triads are commonly used in chord progressions. Learn how first inversion triads are commonly used in chord progressions. Learn how chord progressions tend to follow a common pattern. Learn about root motion and circular chord progressions. Learn about musical phrases and the different types of cadences. Learn about the different types of nonharmonic tones. Learn how the natural and harmonic minor scales combine. Learn about the diatonic seventh chords of major and minor scales. Learn about the five types of seventh chords. Learn how composers arrange the notes of chords. Learn how diatonic triads are identified. Learn how a scale’s notes form special triads. Learn how to correctly spell intervals with a three-step process. Learn how two notes are specifically measured. Learn how two notes are measured on the staff. Learn a method for mathematically calculating key signatures. Learn about key signatures and the special ordering of accidentals. Learn the special names for each note of a scale. Learn how to construct the three different types of minor scales. Learn about half steps, whole steps, and the different types of accidentals. Learn about more complex time signatures. Learn how basic time signatures are classified. ![]() Learn how dots and ties modify the duration of notes. Learn about measures and how many notes each can contain. Learn about five types of notes and how flags affect note duration. Learn about the staff, treble clef, bass clef, ledger lines, and the grand staff. Special thanks to Ricci Adams for creating these lessons and drills and making them available under the Creative Commons License. And don’t be surprised if some of these drills are actually fun! Try to make ear training a part of your regular routine. Remember: just like any skill, music theory and ear training take practice. The following music theory lessons and ear training drills will help reinforce the skills and concepts you have been learning in your group and private lessons since you were young. Who knows – if you study hard now, it may even get you out of 8 AM music theory if you decide to go to music school in college! These skills and knowledge will help you learn your music more quickly, accurately, as well as give you deeper understanding and appreciation of what is happening in the music you hear and perform. It is extremely important for every well-rounded musician to have a solid grasp of music theory and ear training. ![]() Mustang was recently named the world’s best-selling sports car over the past 10 years combined, with the seventh-generation, 2024 model coming soon. In addition, Ford recently completed the renewal of its more than $17 billion in sustainability-linked corporate credit facilities.įord Blue – which has high expectations for profitable growth from its portfolio of iconic gas-powered and hybrid vehicles – had first-quarter revenue of $25.1 billion, EBIT of $2.6 billion and an EBIT margin of 10.4%, all up sharply from a year ago.Īlready the maker of America’s most popular truck for 46 straight years – and top vehicle of any type in the region for 41 years – Ford Blue’s Maverick and Bronco were recognized by Car and Driver among its latest 10 best trucks and SUVs. They enabled continued strategic investments in profitable growth and returns to shareholders, including through a regular dividend payable June 1.Īt the end of the quarter, the company’s persistently strong balance sheet had nearly $29 billion in cash and more than $46 billion in liquidity. ![]() Company adjusted earnings before interest and taxes, or EBIT, were $3.4 billion, an increase of 45% and margin of 8.1%.Ĭash flow from operations in Q1 was $2.8 billion Ford generated $693 million in adjusted free cash flow. Net income of $1.8 billion compared to a net loss in the 2022 period that was primarily attributable to a change in the mark-to-market value of the company’s investment in Rivian. The Ford Blue and Ford Pro business segments were both profitable in every region where they operate. Profitability in the quarter was enhanced by a favorable mix of products, higher net pricing and increased volume and was broadly based geographically. “Ford Pro is leading the way on profitable growth, our big investments in iconic Ford Blue vehicles and derivatives are winning with customers, and Ford Model e’s different approach to EVs is significantly reducing costs on our first high-volume products while rapidly developing breakthrough next-generation vehicles from the ground up.”įord’s first-quarter 2023 revenue reached $41.5 billion, up 20% from the same period a year ago, on shipments approaching 1.1 million vehicles, a 9% increase.Ĭustomers made Ford America’s best-selling vehicle brand in the quarter, choosing its iconic gas-powered, hybrid and electric trucks, commercial vans and SUVs – categories in which the company has demonstrated strengths and made strategic commitments. ![]() “We’re bringing Ford+ to life by zeroing in on what distinct customers need and value the most,” said Farley. Company reaffirms guidance for full-year 2023 adjusted EBIT of $9 billion to $11 billion, adjusted free cash flow of about $6 billionĭEARBORN, Mich., – According to Ford CEO Jim Farley, the first quarter of organizing around and running the company on behalf of distinct customer groups produced solid operating results and a glimpse of the promise of its Ford+ growth plan.Ford Pro EBIT nearly triples, to $1.4 billion, and Ford Blue EBIT doubles, to $2.6 billion, with margins for both exceeding 10%.Quarterly revenue rises 20% year-over-year to $41.5 billion $1.8 billion in net income compares to year-ago net loss of $3.1 billion adjusted EBIT of $3.4 billion was 45% higher.Three customer-focused businesses now drive value, growth: Ford Blue (iconic gas, hybrid vehicles), Ford Model e (breakthrough EVs), Ford Pro (commercial products, services). ![]() Print the charts and take them with you in your purse or wallet while you are traveling. Historical Exchange Rates For Indian Rupee to United States Dollar Quick Conversions from Indian Rupee to United States Dollar : 1 INR 0.0122248 USD. A Lakh Rupee is one hundred thousand rupees and a crore rupee is ten million rupees. 14 Contains the reverse of the aforegoing Table - namely, Dol- lars converted into Rupees at the same rates of Exchange, from 50,000 Dollars to 1 Dollar. Large amounts of Rupees are expressed in lakh rupees or crore rupees. The USD conversion factor has 6 significant digits. The INR conversion factor has 6 significant digits. The USD/INR exchange rate can go up from 81.811 to 84.622 in one year. Prepared money conversions USD to INR conversion 1 USD to INR 0.00 INR 5 USD to INR 0.00 INR 10 USD to INR 0.00 INR 20 USD to INR 0.00 INR 50 USD to INR 0.00 INR 100 USD to INR 0.00 INR 200 USD to INR 0. Will Dollar to Rupee exchange rate grow / rise / go up Yes. The exchange rate for the United States Dollar was last updated on from The International Monetary Fund. This is the US Dollar (USD) to Indian Rupee (INR) exchange rate history summary page, detailing 180 days of USD INR historical data from Tuesday to Friday Highest: 82.933 INR on. USD to INR exchange rate chart USD/INR INR/USD Live 1M 3M 6M 1Y All Please wait. The exchange rate for the Indian Rupee was last updated on from The International Monetary Fund. The United States Dollar is divided into 100 cents. ![]() The Indian Rupee is divided into 100 paise. The symbol for INR can be written Rs, and IRs. The United States Dollar is also known as the American Dollar, and the US Dollar. The United States Dollar is the currency in American Samoa (AS, ASM), British Virgin Islands (VG, VGB, BVI), El Salvador (SV, SLV), Guam (GU, GUM), Marshall Islands (MH, MHL), Micronesia (Federated States of Micronesia, FM, FSM), Northern Mariana Islands (MP, MNP), Palau (PW, PLW), Puerto Rico (PR, PRI), United States (United States of America, US, USA), Turks and Caicos Islands (TC, TCA), Virgin Islands (VI, VIR), Timor-Leste, Ecuador (EC, ECU), Johnston Island, Midway Islands, and Wake Island. Red dot Audio is not supported in your browser. A simple currency converter from United States Dollar to Indian Rupee and from Indian Rupee to United States Dollar. The Indian Rupee is the currency in India (IN, IND). This question is for testing whether you are a human visitor and to prevent automated spam submission. |